siquick

Heart Attack and Stroke Risk Jumps When People Stop Taking GLP-1s

https://nautil.us/whiplash-heart-attack-and-stroke-risk-jumps-when-people-stop-taking-glp-1s-1279029

“Whiplash”: Heart Attack and Stroke Risk Jumps When People Stop Taking GLP-1s

“Whiplash”: Heart Attack and Stroke Risk Jumps When People Stop Taking GLP-1s: Stopping GLP-1 treatments has side effects, too

Mar 20 at 9:42pmWeb
Show threadRobotbeatMar 20
Kind of makes sense that stopping taking a drug that reduces heart attack and stroke risk leads to a return to the higher risk of before.
Show threadTaupeRangerMar 20

Kind of a useless analysis if it doesn't compare the risk after stopping GLP-1s to the risk of NEVER taking GLP-1s in the first place.

We probably don't know the numbers yet, but one can easily envision a scenario like: risk of CE without GLP-1 weight loss: 20%. Risk after taking GLP-1s for 2 years: 10%. Risk after stopping GLP-1s: 12%. "Your heart attack chance goes up 20% after stopping GLP-1s!!!"

Show threadrayinerMar 20

This is a very odd phrasing that makes it seem like heart attack and stroke risk are higher for those who stop taking the drug than those who never took the drug. Moreover, the effect of restarting taking the drug seems attributable to the study design. Those who took a break had higher risk at the end of the study than those who don’t. But those who took a break took the drug for less total time than those who took it for the entire study.

You could characterize these same facts in the opposite way. GLP-1s don’t permanently change your body. They provide benefits while taking them but quickly clear out of your system when you stop taking them. Arguably, that’s a good thing in a drug.

Show threadldayleyMar 20
How much of this could attributed to simply having less artificial hormonal support for not overeating after discontinuing treatment, and falling back into old habits? I’d love to see more research focused on these mechanisms.