Extrachromosomal DNA in Urothelial Carcinoma: Insights and Implications

In recent years, extrachromosomal DNA (ecDNA) has surged to the forefront of cancer biology, emerging as a pivotal factor driving genomic instability and tumour evolution. Nowhere is this more evident than in urothelial carcinoma, a form of bladder cancer notorious for its aggressive behavior and resistance to conventional therapies. New research uncovers how ecDNA rewires cancer cells at the…

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