It's weird that sloppy methodology in 19th century nutritional biology led to the invention of power ups in videogames, but history is like that sometimes.
In 1870 Erich Wolff was studying the iron content in different foods and mismeasured the iron content in spinach. (There's a legend about a misplaced decimal point that seems to be a myth, but his research did lead to incorrectly high scores for spinach and other vegetables.)
Then a few decades later, the newspaper strip Thimble Theatre became a big hit because of a side character, a sailor named Popeye. Popeye could gain tremendous strength by... rubbing a magic chicken.