Interesting and concerning #COVID19 study. It suggests an important and accumulating shift in COVID dangers without specifically forecasting impact.

"Five years after the emergence of SARS-CoV-2, converging clinical evidence reveals a progressive compound immunodeficiency affecting a substantial and growing proportion of the global population... The cross-pathogen pattern further supports a shared immunological driver operating at population scale."

https://www.researchgate.net/profile/Abdul-Mannan-Baig-2/publication/401888724_Spike_Protein-Mediated_Compound_Immunodeficiency_Cascade_in_COVID-19_and_Long-COVID/links/69b333a98c53216c011a6d92/Spike-Protein-Mediated-Compound-Immunodeficiency-Cascade-in-COVID-19-and-Long-COVID.pdf