¿Sabías que se ha reportado que hasta septiembre de 2022 la pandemia de #COVID19 había provocado más 6 millones de muertes a nivel mundial (https://covid19.who.int/)?
Soy de los que cree que ese número es mucho mayor. Nunca sabremos con exactitud los decesos que siendo covid se registraron como «cardiac arrest» u otras condiciones que el virus vascular, inflamatorio y sistémico #SARSCoV2 ha causado.
¿Cuánto más daño crees que se irá descubriendo en años por venir? ¿Cuánta más discapacidad? 😔🥺🤯😢
🔴🟠🟢🔴🟠🟢🔴
¿Sabías que existe preocupación por la sospecha de que #COVID19 no solo infecte, sino que reconfigure permanentemente el epigenoma humano en patrones idénticos a los de Alzheimer y Parkinson? Eso podría desencadenar una futura epidemia de degeneración neurológica.
*Aún se trata de una asociación, habrá que ver si existe relación causal.*
Genome-wide DNA methylation profiling in #COVID19 positive patients reveals alterations in pathways linked to neurological dysfunction
https://link.springer.com/article/10.1186/s13148-026-02094-0
Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly transmissible RNA betacoronavirus, causing coronavirus disease-19 (COVID-19). Infection with SARS-CoV-2 can result in a broad spectrum of clinical outcomes, ranging from asymptomatic or mild to a severe, deadly illness. Emerging evidence suggests SARS-CoV-2 affects host gene regulation through epigenetic mechanisms, such as DNA methylation, potentially contributing to immune dysregulation and post-acute sequelae, including neurological and psychiatric disorders. However, the extent and functional relevance of these epigenetic changes remain uncertain. Methods and results We employed whole-genome methylation sequencing (WGMS) to profile DNA methylation in peripheral blood from SARS-CoV-2-positive patients across a spectrum of symptom severity, ranging from asymptomatic to severe (n = 101), in comparison to SARS-CoV-2-negative individuals (n = 105). We observed a widespread hypomethylation in the genomes of infected individuals, which was more pronounced in severe cases. Notably, we identified differentially methylated genes in patients with mild (19 genes), moderate (19 genes), and severe (35 genes) symptoms. These genes included those involved in canonical immune responses as well as known to be linked to neurodegenerative diseases. Subsequent pathway enrichment analysis further supported the significant association between the differentially methylated genes and those implicated in Alzheimer’s and Parkinson’s disease, as well as neuropsychiatric conditions, suggesting potential epigenetic links between acute SARS-CoV-2 infection and long-term neurological outcomes. Our WGMS comprehensively mapped severity-stratified genome-wide DNA methylation changes in COVID-19 patients. Conclusion Our findings underscore the potential importance of epigenetic regulation in the acute responses to SARS-CoV-2 infection and highlight an overlap with epigenetic mechanisms relevant for neuropsychiatric disease processes.
¿Sabías que la #CovidProlongada ha dejado a muchas personas con enfermedades y lesiones cardiovasculares, __incluso tras una infección leve o asintomática__?
Investigaciones científicas muestran un mayor riesgo de enfermedad cardiovascular meses o años después de la infección. La lesión cardiovascular puede permanecer latente y manifestarse repentinamente. Algunas personas requieren monitoreo cardíaco de por vida, dispositivos y terapias avanzadas.
Shaira Leiza
