COVID-19 Vaccinations and Kidney Disease Outcomes - Dr. Christos Argyropoulos.
https://www.youtube.com/watch?v=StZRHQxcD7Q
https://bird.makeup/users/christosargyrop/statuses/2026005815962812766

One hour talk, worth looking at the timestamps in video description, possibly begin with the summary at the end of the talk. Obviously from nephrology POV, he compares infection vs vaccination rigorously with big data ("accounting" not "sampling" as he puts it). Spoiler: Infection is bad, vaccination isn't.

I was interested to see a couple of indications that the third infection was perhaps significant WRT kidneys:

Timestamp 35:54

…we can see in this data that the first couple of COVID infections are not associated temporarily with a risk for AKI (Acute Kidney Injury). But after the third one, you know, there is a 4 to 8% higher rate of having an AKI. That's… that's kind of concerning. It's a small number for sure, but when you're talking about millions and millions of people, small percentages multiplying with large numbers gives you very large numbers. Interestingly enough, no signal with the vaccine like absolutely nothing…

Timestamp 45:50

…after the first infection, it seems that the slope gets less negative, meaning people don't lose kidney function as fast. The same thing happens after the second infection. And on the third infection, the rate of change in kidney function is actually worse than before the individuals got any any infection. Now, what does this data mean? If you're a nephrologist, this is a scary figure.

It means that the two infections induced a physiological condition called hyperfiltration, meaning the kidneys were filtering the blood much more effectively.

And after the third infection, remember we're looking at data over four years, the pattern had reversed to the point that people were losing slightly faster kidney function…

…if you go and measure what each of these individual filtration units do, it's a huge spread, this 100% is maintained because some units are filtering much more and others are filtering much less. So this is the classical pattern of hyperfiltration and over time the units that are filtering the blood more effectively burn out and then more and more of them die… …and eventually… …end up with kidney failure and need dialysis.