I feel like a lot of people miss the meaning of this one.

A gunshot wound that creates a splatter of red liquid is very, very different in meaning from a splatter of ketchup. The comic is criticizing the type of person who criticizes art only based on the superficial similarity rather than the actual context and meaning represented by the artist’s choices.

Not every artistic choice has intrinsic meaning, and plenty of artists and art critics go too far in focusing on the “how” than the “what” in art, but I still think the “how” matters a lot.