No. Because the very nature of passwords and password managers make you immeasurably safer than not using one at all. Password managers in almost all markets detect password compromises and alert you to change them. Doing so is trivial and as long as you catch it in time, you’re much safer and harder to target than almost any other user.

Passwords are like physical locks. Its not about being unpickable or indestructible. Its mostly about raising the barrier of entry high enough that you are an unappealing target. Why would I spend days/weeks/months trying to crack the account of someone using a random string of 14 characters unique to every service and that can change their password within hours or days–when I could instead gain remote access to hundreds of other users that keep a ‘passwords.doc’ file in ~/documents with open permissions? They likely use passwords like ‘Snoopdog2004$’ so they’re easy to brute force, they won’t notice incursions, and can’t easily change passwords that are shared between multiple services.