That’s pretty incredible. I wonder if the patients will have to get more insulin-producing cells transplanted every few years, or if this is a “one and done” type of deal?

In any case, an autologous cell transplant every ≥3 years or so is a vast improvement over the current situation for type 2 diabetes

IIRC the biologist that runs the YT channel Though Emporium did this some years ago regarding his lactose intolerance and he had to get more after some years because his body didn’t naturally produce them

But I hope this is different

This is a different matter entirely. The person who runs that channel (I love that channel, btw) does not have functional genes to produce lactase (the enzyme that lyses the bonds in lactose). Either he can’t make any lactase, or he can only make insufficient quantities of it.

What he did was introduce lactase producing bacteria into his small intestine. This required him to kill off most of his gut flora and then repopulate it with compatible species, including some lactase producers. So it’s not exactly correct to say that he cured himself of lactose intolerance; he just got something to create lactase for him. He had to repeat the therapy years later because his gut flora changed over time (likely due to shifts in his diet), and the quantity of little lactase producing bacterial buddies living in his intestines declined.

This is blatantly incorrect to a degree that i’d call it an outright lie, spending 30 seconds looking it up would show you that his video is literally titled “I Genetically Engineered MYSELF to Fix Lactose Intolerance”.

Shit - you know what? You’re right. It’s been a while since I saw the video, and I had it mixed up in my mind with a similar video I saw of a guy doing a fecal transplant to fix his lactose intolerance. I went back to check the Thought Emporium video, and yeah - he used a retrovirus to introduce the E. coli lacZ gene into his small intestine’s brush border cells. That’s my bad; sorry about the misinfo. You’re right in that I could have easily looked it up, but I went from memory instead, and it was… unreliable.