I have spent my whole life intimately involved with southern Republicans. They will never ever not vote Republican, let alone vote Democrat. It is an identity marker.
It doesn’t even really matter what the policies are. They’ll complain for a while, but they will always internalize a Republican policy shift no matter what it is. They used to treat “free market economics” as a religion just 10 years ago.
Secondarily, they love to define their identity as opposition to the northeast (a stereotypical fictional version of northeast). Democrats and “coastal elites” are the same to them. Once they elected a black man, they all got more racist. They nominated a woman, then they got more sexist. They campaigned on social programs, fuck the poor (even if they are poor).
And there is a cognitive dissonance between their beliefs and their experience. They’ll say “deport them all” but be personal friends with immigrants from church. They simply don’t connect their political beliefs to their reality.
I’m a southerner and I don’t see a future for this country. I used to think if they felt enough pain, then they would take politics seriously, but then a whole bunch of them died of COVID and it changed nothing. If I was a non-American, I’d be telling my government to do what they can to remove all dependence on this country as possible because it won’t get better.

I don’t really know how we’d get there, but the US would be better structured as an EU of regions, IMO. The states are too small, but we’ve got regions with definite noticeable cultural differences (Northeast vs Southeast, etc etc). These areas have more similar values than the country as a whole, and are big enough to handle 99% of their issues. Like, we should not have done the ACA, just merged all the various already successful Northeastern healthcare systems. Then the South could decide to copy it if they wanted, after they saw it working. Or not. What can you do? Trying to impose it seems to have drastically backfired.

Since these regional governments would be picked from the inside, hopefully there wouldn’t be as much of a contrarian reflex to oppose everything they do.

Kind of, but also it’s complicated. For example, Chicago is blue blue blue. 500 miles in every direction outside the city is red. 90% of the area of Illinois is red. But Chicago is so much more massive that Illinois votes blue in the end. So what the heck region is Chicago in, and the red part of IL?

I don’t know CA well but I know it’s blue with very deep red pockets.

50 miles out of Chicago will get you to red counties.