HPV vaccination reduces oncogenic HPV16/18 prevalence from 16% to <1% in Denmark

https://www.eurosurveillance.org/content/10.2807/1560-7917.ES.2025.30.27.2400820

I would like to add:

- HPVs are extremely common: 80% of men and 90% of women will have at least one strain in their lives. Unless you plan to remain completely celibate, you are likely to contract a strain.

- Sooner is better, but vaccination can be done at any age. Guidelines often lag behind, but vaccination makes sense even if you are currently HPV-positive. While it won't clear an existing infection, it protects against different strains and reinfection (typically body removed HPV in 1-2 years). See: https://pubmed.ncbi.nlm.nih.gov/38137661/

- HPV16 is responsible for a large number of throat cancers (around 50% in smokers and 80% in non-smokers!). This affects both men and women. Vaccinating men is important for their own safety and to reduce transmission to their partners.

Effect of HPV Vaccination on Virus Disappearance in Cervical Samples of a Cohort of HPV-Positive Polish Patients - PubMed

The introduction of human papillomavirus vaccines revolutionized cervical cancer prevention. Our research hypothesis is that HPV vaccination affects the remission of HPV in cervical swabs. We provide a prospective, ongoing, 24-month, non-randomized study in HPV-positive women. We enrolled 60 patient …

PubMed

>> HPVs are extremely common: 80% of men and 90% of women will have at least one strain in their lives.

This statistic seems to be used by some people to avoid the vaccine - they figure they've already had it at some point. The biggest problem with that logic is that not all strains are as dangerous and they probably have not contracted 16 or 18 specifically. The other problem is there's still a good number of people who have never had it and shouldn't assume they have because its common.

> This statistic seems to be used by some people to avoid the vaccine

The FDA itself restricted access to the vaccine on the basis of age. Given that virions aren't even involved in the production process, its safety should have been deemed good enough for the entire population early on.

The reason it's not recommended for all ages is money. Not safety concerns.

Same reason you can't get Shingrix under a certain age.

I would happily pay for Shingrix.
Prepare your happy for a very profit-laden high three-figure bill.
Medium 3-figure at most. $400-600 for the full two-dose series.