@rozeboosje @johncarlosbaez
A lot of computer music doesn't exactly have notation. Instead it has a user interface.
Let's say you have a computer and want to make a very simple chord over A. You can go look for the frequency of the 5th note in the scale or you could just multiply 440 by 3/2. This direct use of fractions is called "just intonation".
The problem with doing this is that the third note in the scale in 12tet is way off from the ideal just intoned fraction. So if you have a perfectly in tune chord on C and then your melody goes to E, that E is going to sound really wrong.
So you could also just make all the notes in the scale just intoned, but if your music goes onto a key change, it can also sound off, unless you retune all your notes to be the just notes relative to the new key. All your As are now a new frequency. This can sound great, but its fiddly.
Changing all the notes in every chord relative to the bottom note in the chord also often sounds wrong and kind of unmoored. Its often better to stick with the scale that belongs to your key because the notes are more stable and you can more easily tell when you're getting to an important note.
There are many composers who write this way but its extra work so most people stick with 12tet.