TL;DR: Dominant #H3N2 #influenza strain this year is new & the star of the season, with that part of the *trivalent* vax not a great match. HOWEVER, the vax is still doing its job of keeping most people out of the hospital.

Each year's vax helps build more diversity in your flu-attacking antibodies. You COULD get that by getting miserably sick every year but the jabs are much safer & give you exposure to 3 strains every year.

RE: https://flipboard.com/@npr/health-930k6cv1z/-/a-0gERmB5DSsifJqvaBD8SlQ%3Aa%3A3195441-%2F0

https://www.npr.org/2025/11/19/nx-s1-5607250/flu-season-h3n2-influenza-virus-shot

This flu season could be a bad one thanks to new variant

Early clues suggest the U.S. may be facing yet another bad flu season this year. The latest flu virus has mutated in ways that present particular challenges for our immune systems.

NPR - Rob Stein

The immune system is a bit like a LLM but it models microbial antigens.

Or not. It’s fuzzy.