Off the top of my head:

• Allows using DoH/DoT/DoQUIC/recursive upstreams without installing extra packages (unbound, cloudflared, etc)
• Allows acting as a DoH/DoH3/DoT/DoQUIC server alongside normal DNS over UDP and TCP
• Allows configuring SOCKS/HTTP proxies for forwarders
• Act as authoritative zone server with DNSSEC signing
• Allows custom responses via plugins (e.g. conditional responses based on client’s IP addresses)
• Accept PROXY Protocol to forward client IPs from trusted load balancers
• All the clustering and zone transfers magic
• DNS64

It really dives deep into the inner workings of DNS and does pretty much anything Pi-Hole does, with many more security and QoL features. Although the UI may feel a bit dated, I’d recommend it to anyone running their own homelab infrastructure beyond just adblocking