David Usharauli"administration of lipid particles loaded with RNA coding for tumour-unspecific antigens"
So much for the painstaking search for tumor-specific #neoantigens. Turns out you can just throw in whatever, or even nothing at all, and it still somehow works.
Sensitization of tumours to immunotherapy by boosting early type-I interferon responses enables epitope spreading - Nature Biomedical Engineering
Lipid particles loaded with RNA coding for tumour-unspecific antigens can enhance early responses of type-I interferons, mediating the success of immune checkpoint inhibitors as well as epitope spreading.