🔗 Parkinson's Disease Might Not Start in The Brain https://www.sciencealert.com/parkinsons-disease-might-not-start-in-the-brain-study-finds

Led by a team from Wuhan University in China, the study is primarily concerned with the alpha-synuclein (α-Syn) protein, which is closely associated with Parkinson's. When production goes awry and creates clumps of misfolded proteins, it interferes with brain function.

The key discovery here is that α-Syn clumps can build up in the kidneys, as well as the brain. The researchers think these abnormal proteins might actually travel from the kidneys to the brain, possibly playing a part in triggering the disease.

Parkinson's Disease Might Not Start in The Brain, Study Finds

Parkinson's disease is traditionally associated with neurological damage in the brain, brought on by a drastic drop in dopamine production, but a new study suggests it could get started in an unexpected part of the body: the kidneys.

ScienceAlert

bioinformatics analysis confirmed favorable binding affinity between α-Syn and SARS-CoV-2 spike (S) protein and nucleocapsid (N) protein, and direct interactions were further verified in HEK293 cells. The expression of α-Syn was upregulated and its aggregation was accelerated by S protein and N protein. It was noticed that SARS-CoV-2 proteins caused Lewy-like pathology in the presence of α-Syn overexpression.

https://pmc.ncbi.nlm.nih.gov/articles/PMC8949667/

SARS-CoV-2 Proteins Interact with Alpha Synuclein and Induce Lewy Body-like Pathology In Vitro

Growing cases of patients reported have shown a potential relationship between (severe acute respiratory syndrome coronavirus 2) SARS-CoV-2 infection and Parkinson’s disease (PD). However, it is unclear whether there is a molecular link between ...

PubMed Central (PMC)