PSA: Don't take 4 packets of paracetamol in one day

https://lemmy.dbzer0.com/post/46139103

American here: I know paracetamol is acetaminophen, but how much is a packet?
Reading the meme it seems like a packet is five times the dangerous dosage.

paracetamol packet

It looks like it’s a sheet of 6-8 pills

nps.org.au/…/paracetamol-ibuprofen-combinations-f…

Paracetamol/ibuprofen combinations for acute pain

Paracetamol/ibuprofen combinations may be an alternative to codeine-based analgesics for short-term management of pain. Find out more

NPS MedicineWise
according to the acetaminophen i’ve got at home, dangerous dosage is >4g per day. that means that if 4 packets was 20x that, each packet would be 20g, which, if they’re normal 500mg pills, would be 40 pills per packet.
you should stick to 3g a day if you’re overall a small person, some bottles will recommend this as the max to be safe

Therapeutic dose of acetaminophen is 15 mg/kg q6h prn. That dose of 4g/day ==> 1g/dose. 1000mg/(15mg/kg) = 66.67kg == 145lb.

That’s the minimum weight for that acetaminophen dosing. If you’re under that weight, you can consider the reduced dose. If you’re over 145lb, no need to worry. And honestly, I think I’m the only one who actually doses this stuff q6h anyway. I think most people end up doing TID dosing because that allows uninterrupted sleep.

3-4000mg is toxic to the liver.
And a maximum of 2g/day if you weigh under 50kg (which not a lot of people know).

Well, generally you’re only supposed to take ~2 tablets at a time, so 10? 40 pills a day is 13,000mg of acetaminophen, or 20,000mg if they’re extra strength.

That’s, uh, bad. You’re recommended to take under 4000mg per day, so that’d be a bit over a packet? Makes sense to me.

For the record, mixing two painkillers without consulting a doctor is also usually a bad idea but way fucking less of a bad idea than taking 13000mg of tylenol in a day.

For the record, mixing two painkillers without consulting a doctor is also usually a bad idea but way fucking less of a bad idea than taking 13000mg of tylenol in a day.

Basically, if something hurts so much that you might take enough paracetamol/acetaminophen to fuck with your liver then you yes, you should be under a doctor’s care. That said, between my wife and me, we’ve had three or four doctors over the years all be very chill with the idea of alternating Tylenol and Ibuprofen after surgery or the like. I guess they work on such different chemical pathways that they don’t have much interaction potential, and keeping under the daily dose of Tylenol in particular is incredibly important, as we’ve seen in this thread.

They act on different systems, yes, but this is more about the metabolism of each.

Non-steroidal-anti-inflamatorirs can cause damage to your stomach and kidneys.

Acetaminophen/Paracetol metabolizes in the liver a similar way alcohol does, and like alcohol has a maximum rate of clearing the toxin.

yes, you should be under a doctor’s care.

That’s not always an option, unfortunately.

tyelonol works on the liver, the others like ibuprofen, naproxen,etc works by inhibiting the cox1 and 2 enzymes. of courses take 2 much of the inhibitors is very similar to aspirin, it can prevent clotting(which in itself is a therapeuthic uses for clotting disorders)

Don’t take my word for it but I think paracetamol and ibuprofen with added codeine can be taken together despite the double codeine as the amount they have is low enough that double is still safe.

Check with a pharmacist first, dosages are going to vary and I am just some guy on the internet.

I don’t think there’s a standard size, but I know they sell them in packages of 3x10 where I live. Eating 4 full packets of those in a day would put you at 15 times the upper recommended daily dosage, for what it’s worth, which is calculated slightly conservatively to not be lethal for any adults
You can also often get high-strength pills for chronic pain that are 665mg instead of the regular 500mg.
I believe I’ve seen them sold in 1g pills where I live as well.
the ones for arthiritis, is around 625mg, with caffiene.
Various countries limit painkillers to small packet sizes and pharmacies only hand them out one at a time, so you can’t overdose as easily/spontaneously, either like the person in the post did due to pain, or for suicidal purposes.
It’s not perfect protection, as you can just go to multiple pharmacies to buy multiple packets, but yeah, you will have to actually go do that and will get told at the pharmacy that you shouldn’t take more, if you’re not aware.
America… I remember seeing “value packs” of Tylenol containing 300 pills
Ironically, for America, this is one area where you are expected to read the label and not be an absolute idiot.

Exactly, I know I can take 2 a day and a couple days and if the pain persists I ought to seek out medical help.

We know how to follow directions, we’re just not fucking gonna

The bottle on my shelf has 350 (new, Costco brand) but I don’t take over the recommended dose for obvious reasons. Guess it expired last year now that I look heh. The smaller bottles cost more per dose so no reason not buy a larger one. This is in Canada, not the US for people curious about other countries.
That math doesn’t quite add up. Sure less per dose sounds good, but if you’re wasting half the bottle then paying a little more per dose but less total cost is still more economical.
It may be less effective but you use it till the bottle is done, it’s not like milk it still works.
I wouldn’t do that because i can’t find any information on what that stuff breaks down when it ages and whether toxicity actually goes up over time
i buy the larger ones online. better than buying the small ones. i do this for anti-histamines too, because i got allergies, i can get 1000tablets for the 1st generations easy, and cheaper pricing for the 2nd generation ones years worth. kirkland has the quality to it, im trying some off-brand(probably chinese made) doesnt seem as effective, and it was a wierd shape.
they sell larger bulk bottles, usually i buy them on amazon, in-stores are usually more expensive.
kids were trying to robotrip on dextromorphan, and now they require ID to buy any cold medicine that contains it.

Yikes! The use of the term “packet” was initially confusing to me. Here in the States it’s not uncommon to see small packets of a single dose of over the counter medicines in gas stations and convenience stores for when you’re not at home and something comes up. The directions for extra strength Tylenol are 2 every 6hrs (1000mg dose) not exceeding 3 doses per day.

I was thinking “4 packets over 3 days, what’s the big deal?”

Worth noting as well that the OP said four packs a day for three days.
i heard some people fitness takes these so they can train excessively longer than normal. it was a news article a certain group was discussing, and they were tellinig a story of a dude doing that.
they sell blister packs for tyelenol, but its usually thr brand name, which is pretty expensive.

Depends on the country I guess.

Here, a packet is 16 tablets of 500mg (acetaminophen) or 200mg (ibuprofen).

We’re limited to 2 packets combined per purchase to reduce the chances of severe overdose.

Package dosing generally suggests 2 tablets per dose, with at least 4 hours between.
Or one tablet for children between 10 and 14.

Best friend’s wife almost died like that. Was in a coma for 3-months until a transplant came through.
I mean… Yeah. There are instructions on the packet. They aren’t supposed to be eaten like candy.
even vitamin gummies can be overdosed to a dangerous degree. Hell, even too much water can kill you, it’s difficult to achieve but it can flush out all the nutrients from your body. Always make sure to know how much of anything is safe to put in your body
Yup. I had a buddy give himself Vitamin A poisoning from eating gummy multivitamins like they were candy.
not vitamin A but i personally can’t have the vitamin C megadoses available in pharmacies. Apprently my body needs less vitamin C than most people, normally it’s very hard to have too much of it, but when i take a megadose like 1000mg (daily recommended is ~100mg) i get incredibly painful stomach cramps, whilst everyone around me is just fine
oh yea it causes the runs, and kidney stones. it doesnt seem as severe as vitamin A toxicity.
vitamin A specifically is toxic. not so much for vitamin D, since people are very deficient in vitamin d.
That’s why paracetamol should be sold in the pharmacy by a pharmacist who asks you for what you are using that stuff and warns you about side effects.
No? People should be allowed to decide that shit for themselves. It’s not anyone’s job to hold your fucking hand when you can just read the label.
Yeah that’s what US Americans call “freedom”, but in other places that’s not what it means. Where do you draw the line? Should people be allowed to buy opiods from the supermarket?

Yes, Tylenol #3 is otc in many countries

In all seriousness though providing drug users a route to buying drugs that were safely and reliably manufactured would both significantly lower harm and significantly limit the impact of cartels (see how they switched to controlling avocado trades as they are now losing the ultra lucrative marijuana market). Further, by not forcing users to go underground for their trade you could not connect them to resources for rehabilitation much more easily and earlier in the process of addiction

So yes you should unironically be able to buy safely manufactured heroin and cocaine and fentanyl in a store. Maybe not the grocery store, but a store

Yeah, problem is people cannot be relied upon to read the label. People are idiots. So it’s a good suggestion to put a gatekeeper (pharmacist) in front of the dangerous stuff to walk people through the dangers verbally.

/thread

As shown above, they don’t read the label. Ironically, you didn’t even read the screenshot that’s the cause of all of this - which disproves your point entirely.

In a family of five, how often would I have to go to the pharmacy under that rule? Keep in mind that menstrual pain is a thing. Or would that just be the cheat code to get a dangerous dose?

How would the different online pharmacies know how often I told that story? Or does your proposal just mean “increased shipping cost”?

Don’t think that’s practical at all.

I don’t know what that would change? You go to the pharmacy, say you have a family of five and menstrual pain? Nobody said anything about limiting the amount of drugs to buy.

Oh sorry maybe I misunderstood. Yes, paracetmol and other painkiller should only be sold in pharmacies. This is the case in Germany but you can buy essentially as much as you want if you tell them it’s for multiple people.

Can you just buy them in a supermarket (I’m guessing USA)?

i really don’t want to live in a society where every move of a literate person is questioned because there’s illiterate people roaming around.

There’s clear dosage information in that leaflet inside every single paracetamol box. If you’re emptying a box a day (let alone 4 boxes a day) and don’t bother checking if that’s safe then this is entirely on you

That’s guys a moron. The bottles are ve4y clear not to take more than the recommended dosage. Its labeled all over the bottle.

I’m kind of pissed that such obvious and preventable idiocy leads to an almost immediate liver transplant.

Yes, that’s just a lucky coincidence for him, but still…

in english, french, spanish, and sometimes german.
Did you ever stop to consider that this person was in so much pain with no other alternatives that they might have done so out of desperation rather than simple ignorance?
If you’re in that much pain, you go to 5he hospital, you dont overdose on Tylenol.

Holy shit. It’s almost like there are systemic barriers that would prevent them from having access to healthcare.

Not everyone can afford a doctor. Welcome to the reality of what people have to go through just to get through their day.

It is entirely an empathy thing, and you lack it.

Typed a whole thing put and then deleted it. Not even going to bother. You’re making inferences you just cant make from the post. I agree, there are systemic barriers to Healthcare, this isn’t that.