Non-UK people should read up about Laurence Fox if they want a good laugh.

Some career highlights:

• Destroyed his acting career and his marriage by being an upper class right wing shit.
• Destroyed his subsequent gig as a right wing pundit on GB News by being too misogynist on air.
• Called some drag queens paedophiles after they called him racist. He was sued for defamation and he countersued. He lost on both counts.
• Stood for election as an MP and lost his deposit.
• Stood for election as London Mayor and lost his deposit.
• Tried to stand for election as London Mayor a second time and didn’t get on the ballot because he didn’t fill in the paperwork correctly
• Stood for election to the London Assembly and lost his deposit.

What’s the opposite of career highlights? Career lowlights?

I imagine so, but I also imagine that whether or not they are highlights or lowlights depends on your frame of reference.