This is going into my undergrad teaching as "yes natural selection still affects humans"
https://www.nature.com/articles/s41586-025-09031-w
Sequence diversity lost in early pregnancy - Nature

Around 1 in 136 pregnancies is lost due to a pathogenic small sequence variant genotype in the fetus.

Nature
@marcrr Can you translate the first couple of sentences into Simple for me?
@sinabhfuil Many human pregnancies don't go to term, i.e. miscarriage. It was know that some are due to large genetic mutations. This study shows that many others are due to small but deleterious (bad for health) mutations, many which are new (the mutation happened in the egg or sperm).
The relevance to human evolution is that mutations which are deleterious are still eliminated: miscarriage due to mutation is a form of natural selection.
@sinabhfuil Important to understand that unlike in sci-fi, mutation is a normal and frequent event, we each carry ≈100 new mutations which our parents didn't have. Most have no consequences, good or bad.
@marcrr Mother Nature saying "I wonder if… oh well, maybe not"