A lingering problem I had was my Wireguard tunnel for client devices.
I have multiple times added some subnet and then had to individually add it to the allowed IPs on each device. I didn't want to just preemptively forward the entire 10.0.0.0/8 block, because that would be asking for trouble.
Now it just dawned on me that if I only use IPv6, that problem is gone. Not once did I have to change the v6 prefix, because I can easily leave enough room to grow.