Are your mail servers suddenly appearing on the #DNSBL (anti-spam DNS Block List) ix.dnsbl.manitu.net?
The widely used #NixSpam DNSBL, operating under ix.dnsbl.manitu.net, has (sadly) seized operations.
https://www.geekersdigest.com/suddenly-listed-on-ix-dnsbl-manitu-net-this-dnsbl-has-seized-its-operations/