Doc Impossible*Long, long sigh*
Trials for an mRNA vaccine for pancreatic cancer have shown a 75% cure rate, when administered after diagnosis. Only 2 patients had their cancer return.
Life expectancy after diagnosis with PanCan, under conventional treatment, is less than a year.
My dad died from pancreatic cancer in 2018.
Im not going to do an explainer thread for why this is an incredibly big deal today. You can ask someone else, or read the study for yourself.
I miss my daddy.
RNA neoantigen vaccines prime long-lived CD8+ T cells in pancreatic cancer - Nature
In a phase 1 trial, patients with pancreatic ductal adenocarcinoma who were treated with surgery and bespoke neoantigen mRNA vaccines combined with anti-PD-L1 and chemotherapy exhibited marked long-lived persistence of neoantigen-specific CD8+ T cell clones, which correlated with prolonged recurrence-free survival at a 3.2-year follow-up.
ruska