*Long, long sigh*

Trials for an mRNA vaccine for pancreatic cancer have shown a 75% cure rate, when administered after diagnosis. Only 2 patients had their cancer return.

Life expectancy after diagnosis with PanCan, under conventional treatment, is less than a year.

My dad died from pancreatic cancer in 2018.

Im not going to do an explainer thread for why this is an incredibly big deal today. You can ask someone else, or read the study for yourself.

I miss my daddy.

https://www.nature.com/articles/s41586-024-08508-4

RNA neoantigen vaccines prime long-lived CD8+ T cells in pancreatic cancer - Nature

In a phase 1 trial, patients with pancreatic ductal adenocarcinoma who were treated with surgery and bespoke neoantigen mRNA vaccines combined with anti-PD-L1 and chemotherapy exhibited marked long-lived persistence of neoantigen-specific CD8+ T cell clones, which correlated with prolonged recurrence-free survival at a 3.2-year follow-up.

Nature

@Impossible_PhD this is incredibly good news

But it would be also a good idea to have a device that can adapt that mrna or produce gene editing vectors to fight or prevent every type of cancer

@vulpinelabs There's a giant host of mRNA vaccines in trials now to eliminate cancers of many types, as well as a wide variety of cardiovascular diseases.

But a magic box that just popped out a vaccine is the realm of science fiction for the time being. For now, we need rigorous testing.

@Impossible_PhD a comprehensive combined modular bioinformatics, simulation and personalized gene editing vector design and production system with harmoniously developed software, hardware and wetware is not sci fi, it's just difficult (and the simulation part is to do in silico testing specific to the individual). But sure, to those who don't understand it, it might resemble amagicbox.
But it's also potentially computationally intense considering how much folding@home took (also covid deniers tried to make the covid vaccine look bad because how quick it was released but it was the funding and work put into it that allowed it to be released quickly and folding@home did some of the work that helped but it was a software that allowed a large network of computers work together on folding proteins)
It would be 27 modules with 520 sub modules worth to do in software alone to do what is being done
But the hardware is also difficult due to how precise it needs to be on top of it supposed to being easily accessible
Had to scrunch this due to char limits