A whopping (~90%) reduction of progression to Type 2 diabetes with tirzepatide (GLP-1 drug, dual receptor) vs placebo in a randomized trial of >2,500 participants with obesity, absolute reduction of 10/100 treated
https://www.nejm.org/doi/full/10.1056/NEJMoa2410819
@erictopol I just told my students today that even though prediabetes is entirely reversible, the condition does as a practical matter tend to worsen, as does the severity of T2DM because weight loss just does not happen. We may be on the cusp of real change.