GlycoShapeOct 14, 2024

Some exciting #glycotime to start the week!

GlycoShape is fresh off the press today on Nature Methods https://www.nature.com/articles/s41592-024-02464-7  

Check out the short thread below 1/6

#Science #ProteinStructure #glycobiology

Restoring protein glycosylation with GlycoShape - Nature Methods

GlycoShape is an open-access web-based platform designed to supplement three-dimensional glycoprotein structures with missing structural information on glycans. To link them, the Re-Glyco algorithm evaluates the steric complementarity of glycans using their conformational ensemble with the protein surface.

Nature
Show threadGlycoShapeOct 14, 2024

2/6 What you see through a camera lens depends on the shutter speed.

Yet we all know that hummingbirds do have wings, and that these are precisely shaped to allow the fast and complex dynamics crucial to their ability to hover and feed on nectar

Show threadGlycoShapeOct 14, 2024
3/6 Analogously, glycoproteins carry beautifully complex sugars, with precise structures and functions, yet invisible due to their fast dynamics and heterogeneous nature
Show threadGlycoShapeOct 14, 2024

4/6 GlycoShape (https://glycoshape.org) is an OA database and toolbox that allows you to restore the 3D structure of glycoproteins with a fast and accurate algorithm named Re-Glyco.

The database counts > 550 glycans to date, largely from the human glycome with examples from all species. For an overview check out the figure below ⬇️

GlycoShape

GlycoShape is an OA database of glycans 3D structural data and information that can be downloaded or used with Re-Glyco to rebuild glycoproteins from the RCSB PDB or EMBL-EBI AlphaFold repositories

Show threadGlycoShapeOct 14, 2024
5/6 GlycoShape was developed with the generous support of ORACLE for Research and funded by the Science Foundation of Ireland (SFI) Additional resources provided by ICHEC and amazing ongoing support from IRIDIS HPC at the University of Southampton
Martin GötteOct 26, 2024
Show threadGlycoShape
6/6 Last but not least GlycoShape was and continues to be developed for and with the #glycotime community  BIG MASSIVE THANK YOU 👏 to all the beta testers around the world. Happy glycosylating!  
Oct 14, 2024 at 9:34amWeb