What comics (including webcomics) have the most distinctive art?

Transmetropolitan, though I have a hard time deciding whether is it the style or the characters. Probably both.

Knights of Sidonia was drawn by an architect. Definitely shows - thel background / landscape shots are quite ridiculously good and give you the scope a lot of comics tend to miss.

Darick Robertson’s art is always great.

The Other End Comics

Extra Fabulous Comics

Romantically Apocalyptic sticks out in my mind.

diggercomic.com

The comic is very black white and has an exceptional story in my opinion.

Digger by Ursula Vernon

Sonichu
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Hitmen For Destiny

Our new heroine

The great thing about Perry Bible Fellowship is that the varying art styles help tell the story.

Unix Surrealism

I personally think the art style is very distinctive compared to just about anything else I’ve seen.