The notion of epimorphism can be quite different from surjection, e.g. in Rings.
Though I recently learned epimorphisms can be characterized in terms of Isbell's zig-zags: https://en.wikipedia.org/wiki/Isbell%27s_zigzag_theorem.
Whereas monic seems to capture the notion of "injective" quite well in a categorical def. And indeed the two agree on any variety of algebras in the sense of universal algebra.