Who are we all descended from? And I mean π‘Žπ‘™π‘™ - people, birds, plants, bacteria, archaea....

It's called π—Ÿπ—¨π—–π—”: the last universal common ancestor. And people have been trying to track it down. By comparing the genomes of different organisms you can infer a tree of life and guess where it leads back to.

This new paper suggests that LUCA lived about 4.2 billion years ago, with a genome having about 2.5 million base pairs.

They guess it was a prokaryote: a single-celled organism with no nucleus. They guess it was anaerobic. Neither of those are at all surprising. More interestingly, they guess it was an acetogen! I hope you know acetic acid is what makes vinegar sour. Nowadays, 'acetogens' are bacteria that power themselves by converting carbon dioxide and hydrogen to acetic acid and water:

2 COβ‚‚ + 4 Hβ‚‚ β†’ CH₃COOH + 2 Hβ‚‚O

This produces less energy than fermentation, which converts glucose to acetic acid. But hey: sometimes there ain't no glucose around.

The paper says that the metabolism of LUCA could have provided a niche for other microbes living at the time, and recycled hydrogen they made. It's the blue box in the web of chemical reactions carried out by early organisms in the picture at left.

At right you see how if bacteria called methanogens were also also around, they could put methane (CHβ‚„) into the atmosphere, which gets broken down to Hβ‚‚ by sunlight. When this dissolved in water, acetogens can eat it!

The paper is open access:

β€’ The nature of the last universal common ancestor and its impact on the early Earth system, https://www.nature.com/articles/s41559-024-02461-1

The nature of the last universal common ancestor and its impact on the early Earth system - Nature Ecology & Evolution

Integration of phylogenetics, comparative genomics and palaeobiological approaches suggests that the last universal common ancestor lived about 4.2 billion years ago and was a complex prokaryote-grade anaerobic acetogen that was part of an ecosystem.

Nature
@johncarlosbaez This is really surprising: "cellular life was already involved in an arms race with viruses at the time of LUCA"

@johnkozak @BartoszMilewski @johncarlosbaez
Aha, someone making a strong but obscurely-phrased point; surely that's a first. πŸ™‚

"The famous oil painting Et In Arcadia Ego is difficult to find out the inter meaning. It is known as the most difficult workings to interpretation in art history."

As with nature of life 4.2 billion years ago.

Which I think is older than the painting; I'll have to check.

@BartoszMilewski - thanks, I hadn't spotted that!

But was there spam?

@johncarlosbaez

@BartoszMilewski

Viruses are like scammers who scam cells to spam themselves so yes

@johncarlosbaez
What we know for sure is that phishing hasn't started until about 530 mln year ago, during the Cambrian explosion.
@BartoszMilewski @johncarlosbaez Not sure exactly what the evidence is for all these things, but the common belief is that RNA predated DNA. Many viruses have RNA polymerases and the like. So the tendency is to think viruses go back to the shift from RNA to DNA. There probably are some old episodes of the This Week in Virology or This Week in Evolution podcasts which go into it, but I don't remember whether it was a dedicated episode or just mentioned in passing.