The upcoming Microsoft Flight Simulator game appears to take the already-incredible FS2020 and integrate basically everything that was on my wishlist to build this more into a real world Earth-based photogrammetry+procgen Elite Dangerous, with all the career/mission types you can think of, passengers, cargo, and the ability to get out and walk around outside your aircraft.

If they pull this off as described, I could drop huuundreds of hours into this game

https://www.youtube.com/watch?v=a6riRXgRsCU

Microsoft Flight Simulator Development Update - Live from FlightSim Expo 2024

YouTube
@stroughtonsmith There is always VATSIM, which connects you to humans taking the role of Air Traffic Controllers and you fly real routes with weather, etc. Not sure if that is what you have in mind, however.