1. I'm supposed to be finishing my taxes but I've got another four hours. So let's talk about an absolute disaster in the US science ecosystem.

The NIH's BRAIN (Brain Research Through Advancing Innovative Neurotechnologies) suffered catastrophic budget cuts—under Biden, no less—and now is unlikely to fund any new grants and will likely cut funding to existing grantees.

https://braininitiative.nih.gov/news-events/blog/brain-director-funding-neuroscience-uncertain-budget-climate

From the BRAIN Director: Funding neuroscience in an uncertain budget climate | BRAIN Initiative

A message to the community from Dr. John Ngai, Director of the National Institutes of Health (NIH) BRAIN Initiative.

2. To be clear, I don't have a horse in this race. I've never applied to this initiative and very much doubt I ever will.

But this is literally a catastrophe for US science. It's bad not to fund this research, *but what is so much worse is to create the perception it would be funded and then bail.*

3. Here's the program director: "While the BRAIN Initiative will not be able to fund programs at the same level as previous years, rest assured that we will continue to support currently active awards, albeit with some adjustments."

4. So why is this worse than just not funding this critical area of neuroscience?

So many reasons. Let me try to enumerate a few of them. I'm confident I won't manage to cover them all, and look forward to others' additional suggestions.

5. This program put out a call for proposals last year, and has another one pending in June.

Researchers put thousands if not tens of thousands of hours that they could have spent doing science into preparing those proposals instead. It looks like NONE of those will be funded.

6. And then there's all the time that researchers spent reviewing those proposals as well. I've written about the deadweight loss of this system — even when some proposals ARE funded — previously. When *no* proposals are funded this is nothing less than a targeted attack on US science.

https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3000065

Contest models highlight inherent inefficiencies of scientific funding competitions

Scientists waste substantial time writing grant proposals, potentially squandering much of the scientific value of funding programs. This Meta-Research Article shows that, unfortunately, grant-proposal competitions are inevitably inefficient when the number of awards is small, but efficiency can be restored by awarding funds through a modified lottery, or by weighting past research success more heavily in funding decisions.

7. So never mind that the NIH wasted massive labor by the best scientists in the game.

It's worse than that. Because in science, universities outsource merit evaluation to the NIH. Want to be hired, promoted, tenured? Go get grants. Never mind that the universities have more, better information.

8. There will be brilliant researchers who invested months to write proposals that ranked in the top 10% — guaranteed funding, normally — who will go unfunded and will be denied tenure as a result.

That is on congress, but it's also on the NIH. They're not babes in the woods. They know congress.

9. The mission of the NIH is not just to advance scientific knowledge. Even more, it is to cultivate a research ecosystem in the US that bolsters academia and industry alike, to the massive benefit of the US economy and world standing.

They just abandoned a generation. It's a catastrophic failure.

10. And training. The US science ecosystem is constructed so that training rests upon research funding. When research funding is eviscerated, training dies. Even if these cuts are rectified in a year, we've lost a year of talent. The best and the brightest this year were forced into industry.

11. Perhaps second order, but there are knock-on effects as well. After this, top investigators aren't going to waste the 100-200 hours it takes to write a research proposal for the BRAIN initiative call that is still out for this June.

If the money does arrive, it won't go to the best people now.

12. It's easy to blame congress. And they deserve it.

But my anger, and this thread, is largely directed at the NIH. Of course politicians harm the best interests of the US at every opportunity to get elected.

The NIH has enough experience to anticipate this and respond accordingly. They failed.

13. US funding agencies need to recognize their role in the scientific ecosystem.

They need to acknowledge *and mitigate* the enormous costs of running grant proposal contests.

They need to be aware of how their decisions are used by universities who find it convenient to outsource evaluation.

14. They need to recognize that a fickle congress can cause catastrophic harm to US science and they need to embrace Eisenhower's vision of science as paramount to national prosperity and security.

"How would we have known congress would do that?" is not acceptable when congress keeps doing that.

15. If the NIH is serious about promoting a biomedical ecosystem in the USA—and this is their whole mission—they need to start taking into account the political realities under which they operate. Anything less is worse than leaving money on the table. It's burning the money in their own wallet.

16. NIH has to dispense with the fallacy that grant proposal contests are without cost to science. They need to mitigate those costs, and they must ensure that whatever costs *are* incurred are repaid in multiples.

This sort of catastrophe should be a national embarrassment. Don't accept it.

/fin

@ct_bergstrom Epic rant. One can substitute almost any US government agency that funds science and tell roughly the same story.

Let me add this: a scientific grant typically covers only a fraction of the cost of running a lab. That means proposal writing is constant, and only a small fraction of your submitted proposals are accepted even if they are excellent. Proposals that are accepted are also subject to available funding. The threat of budget cuts is always there. 😳

@ct_bergstrom I am in the middle of an unplanned career redirection for grant reasons also NIH-related (not BRAIN though) and cannot agree more strongly with all your points. Thank you for putting it so clearly.
@ct_bergstrom
This is out of my wheelhouse
It is a catastrophe
Perhaps corporations cuts across the board lobbies, billionaires think tanks parties probably have a hyper feedback loop
They benifit the most to people working for free. They also care more about what people say and have more money then congress members, some of them are quite invested some interesting global game in tit for tat, with layoffs abound. AI can answer most people’s questions. Rome is the mob.😅
@ct_bergstrom can you elaborate here on what you mean in reference to Eisenhower? I read his farewell address (as an example) as providing a similar warning against a sort of scientific-inudstrial complex, alongside his warning against the MIC. Acknowledging importance, yes, but warning against, in practice, getting government too involved given the inevitability of politicking.
@ct_bergstrom (noting that overall, I agree with you - this sort of outcome is predictable, that it is net destroying value, and ought to be avoided)
@ct_bergstrom #10 is the problem. “Forced into industry” sounds like a good thing to Congress.
@ct_bergstrom
Sure that's definitely an issue but it's almost hardly a roundoff error compared to the usual thing which is 8% of grants are funded maybe 12% on a good year. Instead of a 90% chance that you won't get any money now we have 100% chance. It hardly changes the number of wasted hours.

@dlakelan

I wrote a whole-ass paper about the terrible waste of grant proposal contests and I guarantee you that this is not your best take.

@ct_bergstrom
"The purpose of a system is what it does" that's the best take. The NIH the purpose is to funnel money into universities it literally does not matter what the research output is if it did they wouldn't do such a terrible terrible job choosing what to fund.
@ct_bergstrom
If it mattered people like Kariko wouldn't have spent 20 years scraping together peanuts here and there in order to be able to create the vaccine that saved more people in its first year than any other vaccine in the history of the universe.
@ct_bergstrom
If we want it to actually function for the benefit of society it must be torn to the ground and rebuilt you're not going to tweak this system to make it work.
@dlakelan While a cynic I'm not that much of a teleofunctionalist.
@ct_bergstrom
Donella Meadows is the hero here. I strongly recommend anyone with an interest in the improvement of institutional functioning read her book "Thinking in systems". It's not about cynicism it's about reality you can't change a thing without changing the rules and the relationship between the parts. Just asking people to "do better" is guaranteed to fail. Anyway I'm not really here to ruin your night. Maybe some readers will get an interest in that book though
@ct_bergstrom if this makes you mad wait until you see how much money goes towards the next high energy particle accelerator
@katchwreck I think you are missing the point. I am not second-guessing priorities. I'm saying that calling for proposals and then not funding any because congress fucks you — that's straight up burning money, knowingly.
@ct_bergstrom i get that part. but 99% of that funding would go towards publishing papers that never get used for any real world problem solving. no offense but PhDs tend to be overspecialized and not focused on following through with product development based on their scientific results. so i would argue that the bigger issue is big science as an inefficient problem solving machine. pure science has its place but the world really needs now is to parallelize and scale the "Bell Labs" model

@katchwreck

These claims are in desperate need of citations.

@ct_bergstrom it's times like these when a quick Vulcan mind meld would be very efficient :)
@ct_bergstrom @katchwreck Spot on. It takes a lot of sleepless nights putting a proposal together. A lot of hard work. This is why researchers leave.

@ct_bergstrom

Your first sentence = must-follow.🤓🕐

Carl T. Bergstrom (@[email protected])

1. I'm supposed to be finishing my taxes but I've got another four hours. So let's talk about an absolute disaster in the US science ecosystem. The NIH's BRAIN (Brain Research Through Advancing Innovative Neurotechnologies) suffered catastrophic budget cuts—under Biden, no less—and now is unlikely to fund any new grants and will likely cut funding to existing grantees. https://braininitiative.nih.gov/news-events/blog/brain-director-funding-neuroscience-uncertain-budget-climate

FediScience.org
@RossGayler Yeah, it’s dire over there, in more field/funding agency than just that one!
@ct_bergstrom The whole federal government funding is an absolute disaster. Welfare allocation awards can fluctuate wildly from year to year even though it’s just the same people. FEMA will fight you harder than any insurance claim adjuster and if they finally do pay you it can be 7+ years after the disaster. I’m convinced that our federal government is actually run by evil super villains.
@ct_bergstrom To be fair it is Congress that has done this.
@ct_bergstrom Ya, doing the late slog through my taxes right now and really trying not to be distracted, but here I am.

@ct_bergstrom
I was a computational neuroscientist at the time, and I got to hear a lot of inside commentary.

This initiative was started purely as a response of the Human Brain Project in the EU. The purpose was more about managing the optics and keeping human talent, not about the research itself.

And now that Human Brain has finished, the overall reason for this projects existence is gone. Absent a rival project, this was never the best way to organize or fund this research.

@ct_bergstrom
Which is not to say you're wrong in any way. I'm saying that if you were going to do this sort of thing to any large scale initiative, this one would have been high on anybody's list.

This is also, unfortunately, not the only funding whiplash to hit neuroscience. It's been nothing but boom and bust cycles as long as I've had an interest in the field. I'm happy I got the hints and left research when I did.

@ct_bergstrom this is terrible to hear. When I suffered a concussion that led to a 24/7 migraine for nearly 2 years and my health insurance only wanted to cover pills, the only way I finally learned that the combination of loooong migraine and TBI had led to a mild stroke was through a study at NIH. I’m very grateful that I could start getting my life back as a result, bc then I got medical leave and treatment.
PS, 9 marathons later now.

@obrien_kat that’s a remarkable story and I’m so glad you were able to get to the bottom of what had happened and start to recover.

Also, I’m in awe at the nine marathons. It’s fantastic.

@ct_bergstrom thank you, I’m very fortunate and grateful.
Research is important! Especially related to the brain, where our knowledge is behind that of many other areas of medicine.
Thank you!
@ct_bergstrom also, I would like to note that many people made excuses for issues I was having, even not remembering how to get home from work, saying we all forget things as we get older (I was 32 and had gotten two Ivy League master’s degrees the prior year). And pain is perpetually underestimated as a problem.

@ct_bergstrom
I’m supposed to be grouting a floor in the next 4 hours.

Hopefully I decide to reflect on your thoughtful insightful toot though .

I know I’m biased but I nearly always appreciate your posts and grateful to know you exist.

Many who I have encountered only know what they know.

I suppose they assume their worldview is accurate.

I also suppose it’s more or less a metaphor for their personal perspective of our shared reality in nature.

@ct_bergstrom

What I meant to say, I’ll try:
Plainly speaking

From attempting to learn from you and others academia at a distance and others from UW, and SFI.

I’ve learned to challenge myself and appreciate the awe life and nature itself at a whole different scale.

I think we need more collaboration and innovations in perception and research , quan&qual incentives at scale. To have the grace and humility to enjoy the complex simplicity collectively of nature for our future.

@ct_bergstrom that sounds like a system that was beyond broken from the start