New section on getting started with #Guix System:
https://guix.gnu.org/manual/devel/en/html_node/Getting-Started-with-the-System.html
https://guix.gnu.org/manual/devel/en/html_node/Getting-Started-with-the-System.html
Just kidding.
The Guix Manual clarifies possible hardware limitations, which, to be honest, are not that hard to work around. I myself have several machines running Guix System in its both pure-libre and proprietary-polluted forms.