Trans fem here, and HRT somehow made my ADHD worse, which was interesting…

There’s a lot of research suggesting cis women with ADHD have symptoms (and metabolism of stimulant medications) fluctuate with hormone cycles. It’s not talked about enough that HRT would cause similar issues for trans fem folks. There isn’t great research on just how those effects would show up for trans people, but it’s reasonable to assume they would.

Conversely, estrogen and the like can mitigate psychotic symptoms so maybe that’s a side bonus?

Me, currently awake at three am on the first day of my period: did you say medication metabolism?