Marc VeldhoenEnhanced SARS-CoV-2 humoral immunity following breakthrough infection builds upon the preexisting memory B cell pool
How did the 3rd dose of SARS-CoV-2 vaccination and subsequent Omicron breakthrough infection influence antibody and memory B cells?
Serum antibodies had enhanced neutralization capacity after the third dose of vaccination. A subsequent breakthrough infection substantially increases the frequency of B cells encoding SARS-CoV-2–neutralizing antibodies. But....
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this is largely due to the selection of preexisting B cell clones. broadly reactive memory B cells arose early and even neutralized highly mutated variants like XBB.1.5 that the individuals had not encountered. Immunity is selected on conserved epitopes.
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