The University of Pennsylvania is acting proud of Katalin Karikó now that she's won a Nobel. But they kicked her out of her research assistant professor job when she insisted on doing the work that won her that prize:

"She recalls spending one Christmas and New Year’s Eve conducting experiments and writing grant applications. But many other scientists were turning away from the field, and her bosses at UPenn felt mRNA had shown itself to be impractical and she was wasting her time. They issued an ultimatum: if she wanted to continue working with mRNA she would lose her prestigious faculty position, and face a substantial pay cut.

”It was particularly horrible as that same week, I had just been diagnosed with cancer,” said Karikó. “I was facing two operations, and my husband, who had gone back to Hungary to pick up his green card, had got stranded there because of some visa issue, meaning he couldn’t come back for six months. I was really struggling, and then they told me this."

"While undergoing surgery, Karikó assessed her options. She decided to stay, accept the humiliation of being demoted, and continue to doggedly pursue the problem. This led to a chance meeting which would both change the course of her career, and that of science."

Elsewhere she recalled:

“I thought of going somewhere else, or doing something else. I also thought maybe I’m not good enough, not smart enough."

She's now an adjunct in UPenn's neurosurgery department. Will they fast-track her for tenure now that she has a Nobel, or just live with the shame?

Both quotes here come from interesting stories. The first is from here:

https://www.wired.co.uk/article/mrna-coronavirus-vaccine-pfizer-biontech

The second is from here:

https://billypenn.com/2020/12/29/university-pennsylvania-covid-vaccine-mrna-kariko-demoted-biontech-pfizer/

How mRNA went from a scientific backwater to a pandemic crusher

For decades, Katalin Karikó's work into mRNA therapeutics was overlooked by her colleagues. Now it's at the heart of the two leading coronavirus vaccines

WIRED UK

@johncarlosbaez

Thank God for her personal #passion, her #intellectualIntegrity, and her overall #resilience. #respect

@greg_b - yes, she wrote:

“If you are working to please a company or boss then get ready for disappointment. You cannot make a goal to please someone else. You have to tell yourself you want to understand something – because then you’ll never get disappointed. Even if someone publishes something related to the work you’re doing, that’s ok. Because that will help you understand that particular part of your work. It just takes a small change in perspective and you could be so much happier.”

https://inews.co.uk/news/science/katalin-kariko-covid-19-vaccine-pioneer-urges-more-girls-and-young-women-to-take-up-science-1460380

Katalin Karikó: Covid-19 vaccine pioneer urges more girls and young women to take up science

The 67-year-old Hungarian biochemist has been catapulted into the global spotlight thanks to her work in developing mRNA technology, which was used as the basis for the Moderna and Pfizer/BioNTech jabs.

inews.co.uk