I run arch exclusively and find gaming to be pretty seamless and enjoyable, but it does require some config. This is mostly because arch makes no assumptions so dependencies installed by default on other systems are likely not present unless you installed them.

I suggest running Lutris since it handles wine prefixes. Wine prefixes essentially do the work of keeping your individual game installs compartmentalized so each game has all the required dependencies to run properly.

Regardless of whether you use Lutris, the maintainers of that software have good documentation on installing wine and its dependencies here. The guide has a section for Arch and is particularly helpful for ensuring you have all appropriate vulkan or nvidia drivers and driver dependencies installed.

Best of luck if you decide to go down the arch path!