The transition for me personally was fortunately pretty smooth due to having touch typed properly on a normal row staggered board. My first columnar staggered keyboard was the 3W6. It of course felt different and your muscle memories have to slightly adapt but it was worth while with the added comfort a columnar staggered board in a split layout provided. So if you are already touch typing properly I think you get used to it just fine. The harder part at the beginning will probably be finding the right keymap since having fewer keys using mod tap, combos and layers will be mandatory :D.