The only issues I have are with the Battlenet launcher, it sometimes crashes during startup when first opening D4 seemingly at random but once the game is running I don’t have any issues. Currently running it on Proton Experimental.

As far as settings go, at default settings D4 seems to be extremely taxing on the GPU (constant >=97% usage, high temps, crashes regularly after running for a while), although this seems to be common to all systems including PS5/Xbox.

Locking refresh rate and in-game menu FPS to 50fps keeps the power and GPU usage much lower and I get stable performance with no crashes.