A randomized trial in #smokers with major depressive disorder found that #varenicline improved smoking #abstinence versus placebo at 27 weeks without elevating rates of adverse events. Behavioral activation for smoking cessation did not outperform standard behavioral treatment, with or without adjunctive varenicline therapy. https://onlinelibrary.wiley.com/doi/full/10.1111/add.16209?campaign=wolearlyview