Marcel SchulzRT @minouye271
The strongest polygenic risk scores I've seen are for autoimmune diseases, e.g. type 1 diabetes and ankylosing spongylitis (cuz HLA of course)
Anyone seen another disease with PRS AUC~0.92-93 (or even better)?
Development and Standardization of an Improved Type 1 Diabetes Genetic Risk Score for Use in Newborn Screening and Incident Diagnosis
OBJECTIVE. Previously generated genetic risk scores (GRSs) for type 1 diabetes (T1D) have not captured all known information at non-HLA loci or, particularly, a