Ms. Opossum (now @ratnegative)
Tan et al, 2023: Infection with pre-#omicron variants + 0/1/2/3 shots, BA.1 and BA.2 infection + 0/1 shots provided no protection against XBB infection. Additionally, "hybrid" immunity against #XBB waned more quickly than against BA.4/5. #COVID19
https://www.reddit.com/r/COVIDZero/comments/11seglm/tan_et_al_2023_infection_with_preomicron_variants/
Tan et al, 2023: Infection with pre-omicron variants + 0/1/2/3 shots, BA.1 and BA.2 infection + 0/1 shots provided no protection against XBB infection. Additionally, "hybrid" immunity against XBB waned more quickly than did the same against BA.4/5.

Posted in r/COVIDZero by u/anarchodelphis • 1 point and 0 comments

reddit
Mar 16, 2023 at 12:27amWeb
Show threadMs. Opossum (now @ratnegative)Mar 16, 2023
Direct link: https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(23)00060-9/fulltext
Protective immunity of SARS-CoV-2 infection and vaccines against medically attended symptomatic omicron BA.4, BA.5, and XBB reinfections in Singapore: a national cohort study

Protection against XBB reinfection conferred by a previous omicron infection with vaccination was lower and waned faster than protection against BA.4 or BA.5 reinfection, which is indicative of the greater immune evasiveness of the XBB sublineage. Although severe COVID-19 is uncommon, populations remain vulnerable to future reinfection waves from emerging SARS-CoV-2 variants despite high rates of vaccination and infection, as reflected by substantially higher reinfection rates during Singapore's XBB wave than during the previous BA.5-driven wave.

The Lancet Infectious Diseases