@Ffangohr @skuwamoto Shift + E also toggles the Prototype panel!
If you’re on Mac you can also map custom app-specific shortcuts at the system level (https://support.apple.com/en-me/guide/mac-help/mchlp2271/mac).
Finally, you can launch prototyping mode from the command bar (⌘ + /) in less than a second, albeit with more key presses.
Hope one of these helps ✌️