Thiago Carvalho

'We further demonstrated that cGAS mediated inflammation by acting as a macrophage polarization switch, which promoted peritoneal macrophages and the bone marrow–derived macrophages to the inflammatory phenotype (M1) via the mitochondrial DNA–mTORC1 pathway.'

#immunology #InnateImmunity

https://journals.aai.org/jimmunol/article-abstract/doi/10.4049/jimmunol.2200351/263495/cGAS-Mediates-Inflammation-by-Polarizing?redirectedFrom=fulltext

cGAS Mediates Inflammation by Polarizing Macrophages to M1 Phenotype via the mTORC1 Pathway

Key Points. cGAS promotes the macrophage phenotype switch to the M1 phenotype via the mTORC1 pathway.cGAS is activated by mtDNA and further acts as a polarizati

American Association of Immunologists
Mar 4, 2023 at 9:48amWeb
Show threadAdam Hume PhDMar 4, 2023
@cyrilpedia
Maybe it's because I gave up coffee, but I'm having a difficult time wrapping my head around the grammar of this sentence. To the point that it isn't clear to me what they're trying to say.
Show threadGabriele PollaraMar 12, 2023
@adam_hume @cyrilpedia The impact of the paper also relies on the notion that M1 bad, M2 good. In reality macrophages take on a spectrum of phenotypes, and pathology mediated by them is context & phenotype dependent.