Intraoperative sequencing with DNA methylation information using ONP technology. A glimpse of emerging real time medical genomics decision support possibilities from innovative sequencing platforms.
https://www.medrxiv.org/content/10.1101/2023.01.25.23284813v1
There’s a 2021 paper from a Norwegian group that precedes this new preprint:
Intraoperative nanopore sequencing combined with machine learning diagnostics was robust, sensitive, and rapid. This strategy allowed DNA methylation-based classification of the tumor to be returned to the surgeon within a timeframe that supports intraoperative decision making.
John Greally