Dimitri FabrègesJan 27, 2023

[ preprint ]
Stochasticity controls robustness in embryogenesis.

Although it may sound counterintuitive, this is one of the conclusions we defend in our preprint "Temporal variability and cell mechanics control robustness in mammalian embryogenesis" (bioRχiv: https://www.biorxiv.org/content/10.1101/2023.01.24.525420v1)

Show threadDimitri Fabrèges
1. Variability in cleavage timing is surprisingly not regulated at all in mouse embryos (similar observation in rabbit and monkey). We showed that cleavage timing is compatible with a simple accumulation of randomly shorter/longer cell cycle lengths leading to desynchronisation.
Jan 27, 2023 at 11:23amWeb