The mystery of @genentech's monovalent BRD degraders equipped with a propargyl "degradation tail" has been solved by researchers @abbvie: a #CRISPR screen reveals molecular glue-like recruitment of #DCAF16.
#TargetedProteinDegradation #MonovalentDegraders
https://pubs.acs.org/doi/full/10.1021/acschembio.2c00747