For patients with cardiovascular risk factors, getting the flu can substantially increase the risk of a serious or even fatal cardiac event. Getting the influenza vaccine can substantially reduce that risk, even if you do wind up contracting the seasonal virus.
@augieray Every flu season I know at least one person who gets both Influenza A and B (sometimes at the same time!).
And you're incorrect about influenza and its evolution- the molecular structure of the HA and NA proteins of that virus changes in a way that evades prior immunity. " It also is possible for a single change in a particularly important location on the HA to result in a flu virus becoming antigenically different." https://www.cdc.gov/flu/about/viruses/change.htm
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@augieray Whereas a single change on the spike protein of the SARS-CoV-2 virus has not been shown thus far to create an antigenically different virus in the same way. Scientists have shown decreased immune response to some of the new variants and sub-variants vs the OG version, but they're still a partial antigenic match in a way that exposure to OG sars-2 virus or any of the variants still offers protection against other variants/subvariants. In a way that isn't true w/ influenza.
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@TamarYellin BTW, I'm also not sure you're accurate on how antigenically different the recent COVID variants are. "These observations suggest that XBB is antigenically different from the other Omicron subvariants including BQ.1.1, and therefore, remarkably evades the BA.2/5 infection-induced herd immunity in the human population."
https://www.biorxiv.org/content/10.1101/2022.12.27.521986v1.full.pdf
@augieray That article is a preprint and hasn't been peer reviewed. It's intriguing though and I think they did a lot of good work from what I can see.
And far from being a covid minimizer or denier (I was actually a participant in the OG Pfizer vaccine study), it's important to realize that the original Nature article you posted is nearly a year old and looks at a very specific subset of Americans- veterans- which is extremely skewed male (who we know have higher cardiac risks). /1
Also, the covid infected cohort in that Nature study was nearly COMPLETELY UNVACCINATED. I highly doubt that you would arrive at the same results if you used a larger population model (like Kaiser Foundation) and included vaccinated and boosted people.
I didn't realize at first that you were citing this older Nature article, of which people have poked a lot of holes in their methodology already.
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