Steve Shea

Basal forebrain cholinergic neurons differentially respond to cues that often lead to reward versus cues that rarely lead to reward. The magnitude of the response is correlated with reaction time.

https://www.sciencedirect.com/science/article/pii/S2589004222020879?via%3Dihub

Jan 3, 2023 at 4:28pmWeb
Show threadMark Baxter 🏳️‍🌈💉🧂Jan 3, 2023
@neuroshea why on earth did they image HDB neurons for this kind of task?
Show threadSteve SheaJan 3, 2023
@markgbaxter you mean as opposed to NBM?
Show threadMark Baxter 🏳️‍🌈💉🧂Jan 3, 2023
@neuroshea yes, especially given the well established role of NBM cholinergic neurons in associative learning and responses to surprising stimuli, as well as their cortical targets that are more relevant to this task than targets of HDB
Show threadSteve SheaJan 3, 2023
@markgbaxter exactly. I looked through the paper very quickly and they are mostly referred to as “basal forebrain cholinergic neurons” but now I see in several places they identify them as HDB specifically. NBM/SI would have been my first choice for the same reasons, so I just assumed they were recording from the auditory cortex projecting BF.
Show threadMark Baxter 🏳️‍🌈💉🧂Jan 3, 2023
@neuroshea I believe the BF neurons that project to auditory cortex are more caudal (so posterior to HDB). HDB mainly targets piriform, entorhinal, and olfactory bulb. As they say, choices.