I've lost the reference to a classic paper on cortical inheritance in some sort of unicellular ciliate: a tiny piece of the cortex was rotated and implanted, and then stably propagated in the lineage. That region's backwards-facing cilia would sweep food back out of the mouth, leaving them on perpetual brink of starvation. it had the great line that "their normal genome was powerless to help." Anyone know the paper reference?