Brain fog could be caused by stressors impacting the prefrontal cortex (PFC).

Neuroinflammation drives kynurenic acid production, from kynurenine by kynurenine aminotransferase isozymes (KAT II), which blocks N-methyl-D-aspartate (NMDA) receptors, reducing the dorsolateral prefrontal cortex (dlPFC) neuronal firing needed for higher cognition.

N-acetylcysteine (NAC) works by inhibiting KAT II to reduce production of kynurenic acid.

https://medicine.yale.edu/news-article/potential-new-treatment-for-brain-fog-in-long-covid-patients/

Potential New Treatment for “Brain Fog” in Long COVID Patients

While the number of patients they studied is too small for their results to be definitive, Yale researchers—using their extensive experience with two existing

Yale School of Medicine