The field of immunology has lost a giant in Emil Unanue. To the surprise of no one who knew him, he fought off glioblastoma for far longer than the prognosis would suggest. He won the Lasker prize in 1995 for his work on antigen processing that forms the basis of our textbooks. He didn't offer praise often or lightly, but when he did, boy it felt good. This simple email to me after a seminar, when I was an assistant professor, lifted my spirits for weeks! We will miss him.